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Yonghong Liang Ph.D. Curriculum Vitae

Yonghong Liang Ph.D. Curriculum Vitae

Prestasi utama

Pengalaman Riset

  • Sep. 2006-saiki Nggarap Ph.D (Kimia Organik)
    projects
    1. Sinau teoretis interaksi antara dapivirine (TMC120) lan HIV-1 reverse transcriptase
    2. Studi hubungan struktur-aktivitas kuantitatif diarylpyrimidine diowahi benzil
    3. Studi, sintesis, lan studi SAR saka diarylpyrimidine α utawa β naphthyl sing diganti minangka inhibitor non nukleosida saka transkrip reverse HIV-1
    4. Desain lan sintesis DABO minangka inhibitor dual HIV-1 reverse transcriptase lan integrase

  • 2003-2006 Calon Guru
    projects
    1. Transfer proton intramolecular dhasar lan semangat kanggo 2-hydroxybenzophenone, 8-hydroxy-4H-naphthalen-1-one, 5-hydroxy-4, 5-naphthoquinone, 1-hydroxy-9, 10-anthraquione, 7- Hydroxy -1-indenone, 5, 8-dihydroxy-1, 4-naphthoquinone), 4, 9-dihydroxyperylene-3, 10-quinone lan hypocrellin A diteliti kanthi cara teoritis.
    2. Transfer proton inermolekular lemah ing komplek 5-hydroxyisoxazole-banyu, dimer basa basa DNA lan basa-N-methylformamide ditindakake dening metode DFT.
    2002-2003 Hubungan kuitansi-kuantitatif sajrone sipat fisiko-kimiawi saka keton lan aldehida

Awards

Keunggulan Tiongkok Hunan Tesis Master, 2008

Publications

1. Liang, YH; Chen, perhitungan FE ONIOM DFT / PM3 ing interaksi antarandapivirine lan reverse transcriptase HIV-1, sawijining panaliten teoretis. Obat Discov. Dadi 2007, 1, 57-60.

2. Liang, YH; Chen, studi FS QSAR kanggo diarylpyrimidines marang HIV-1 reverse transcriptase tipe-tipe liar lan mutant. Eur. J. Med. Chem. 2009, 44, 625-631

3. Liang, YH; Feng, XQ; Zeng, ZS; Chen, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. Desain, Sintesis, lan SAR saka Diarylpyrimidine Naphthyl-Substituted minangka Inhibitor Non-Nukleoside HIV-1 Reverse Transcriptase. ChemMedChem 2009, 4, 1537-1545.

4. Feng, XQ; Liang, YH; Zeng, ZS; Chen, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. Structural Modifications of DAPY Analogues with Potent Anti-HIV-1 Activity. ChemMedChem 2009, 4, 219.

5. Zeng, ZS; Liang, YH; Feng, XQ; Chen, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. Mimpin optimalisasi diarylpyrimidines minangka inhibitor nukleosida transkripase HIV-1, ChemMedChem 2010, ditampa.

6. Liang, YH; Yi, PG Studi teoritis babagan struktur, transfer proton energetik lan intramolekul alkannin. Chemical Physics Lettters, 2007, 438, 173.

7. Liang, YH; Yi, PG; Peng, HL Studi teori, transfer hidrogen energik lan intramolekul hypocrellin A. Kimia Fisika Lettters, 2008, 466, 6-10.

8. Liang, YH; Yi, PG. Cao, CZ Sinau teoretis ing transfer proton dibantu kanthi solvent ing 5-hydroxyisoxazole. Jurnal Struktur Molekul: Theochem, 2005, 729, 163-167.

9. Yi, PG .; Liang, YH; Cao, CZ Intramolekul proton utawa transfer hidrogen-atom ing lemah lan nyenengake 2-hydroxybenzophenone: A Study teoretis. Fisika Kimia, 2005, 319, 297.

10. Yi, PG .; Liang, YH Studi teoritis saka konjugasi lan efek tambahan ing transfer proton intramolekul ing negara lan negara sing bungah. Fisika Kimia, 2006, 322, 382.

11. Yi, PG .; Liang, YH Tang, ZQ Teoretika nyinaoni reaksi transfer reaksi proton intermolekul ing kompleks 5-hydroxyisoxazole-terasing. Fisika Kimia, 2006, 2006, 322, 387.

12. Liang, YH; Zeng, ZS; Feng, XQ; Chen, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. Sintesis Paralel lan Evaluasi Biologis Diarylpyrimidin dengan Kegiatan Anti-HIV-1. Med. Chem. 2010, 18 (13), 4601.

13. Liang, YH; Zeng, ZS; Feng, XQ; Chen, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. Desain DABO minangka minangka inhibitor dual HIV-1 reverse transcriptase lan integrase. J. Med. Chem.

14. Chen, FE, Liang, YH Perkembangan Anyar ing Obat Anti-AIDS Multi-Target, Progess in Chemistry Medis (8), Peng, SQ Ed., 2011, 167.

15. Chen, FE, Liang, YH, Zeng, ZS PCT / CN2009 / 075931.

16. Zeng, ZS, Liang, YH, Zhang, JY, Xiong, JC China Patent, CN201110070027.4

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